Woman Who Had Uterine Transplant from a Dead Donor Gives Birth

Brazilian doctors are reporting the world’s first baby born to a woman with a uterus transplanted from a deceased donor.
Key points:

The mother became pregnant about seven months after the transplant
After the birth, doctors removed the transplanted uterus
Uterus transplants are expected to help doctors better understand lingering mysteries about pregnancies

Eleven previous births have used a transplanted womb but from a living donor, usually a relative or friend.

The baby girl was delivered last December by a woman born without a uterus because of a rare syndrome.

The woman — a 32-year-old psychologist — was initially apprehensive about the transplant, said Dr Dani Ejzenberg, the transplant team’s lead doctor at the University of Sao Paulo School of Medicine.

“This was the most important thing in her life,” he said.

“Now she comes in to show us the baby and she is so happy.”

The woman became pregnant through in vitro fertilisation seven months after the transplant.

The donor was a 45-year-old woman who had three children and died of a stroke.

The recipient, who was not identified, gave birth by caesarean section.

Doctors also removed the womb, partly so the woman would no longer have to take anti-rejection medicines.

Nearly a year later, mother and baby are both healthy.

Ten earlier attempts using deceased donors in the Czech Republic, Turkey and the US have failed.
Five doctors wearing scrubs and hairnets chat in the busy corridor of a hospital.
Photo: Dr Wellington Andraus (left) and Dr Dani Ejzenberg (second left), confer with colleagues. (AP/Supplied: Dr Wellington Andraus)

Two more transplants are planned as part of the Brazilian study.

Details of the first case were published on Tuesday in the medical journal Lancet.
Uterus was preserved in ice for nearly eight hours

Uterus transplantation was pioneered by Swedish doctor Mats Brannstrom, who has delivered eight children from women who received wombs from family members or friends.

Two babies have been born at Baylor University Medical Centre in Texas and one in Serbia, also from transplants from living donors.

In 2016, doctors at the Cleveland Clinic transplanted a uterus from a deceased donor, but it failed after an infection developed.

“The Brazilian group has proven that using deceased donors is a viable option,” said the clinic’s Dr Tommaso Falcone, who was involved in the Ohio case.

“It may give us a bigger supply of organs than we thought were possible.”

The Cleveland program is continuing to use deceased donors.

Dr Falcone said the fact that the transplant was successful after the uterus was preserved in ice for nearly eight hours demonstrated how resilient the uterus is.

Doctors try minimise the time an organ is without blood flow.

Other experts said the knowledge gained from such procedures might also solve some lingering mysteries about pregnancies.

“There are still lots of things we don’t understand about pregnancies, like how embryos implant,” said Dr Cesar Diaz, who co-authored an accompanying commentary in the journal.

“These transplants will help us understand implantation and every stage of pregnancy.”

AP

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