Research: New Means To Fight Un-killable Bacteria In Healthcare Settings

Scientists at the Research Institute of the McGill University Health Centre (RI-MUHC) have identified new means of fighting drug-tolerant bacteria, a growing global threat as menacing as drug-resistant microbes. Little is known about the mechanisms leading to tolerance, a strategy that makes bacteria “indifferent” to antibiotics and almost “un-killable,” which results in chronic infections extremely difficult to treat and cure.
The RI-MUHC’s research team discovered a new cellular target that can weaken the bacterium Pseudomonas aeruginosa, a daunting microbe which can become highly tolerant to many antibiotics, and thus refractory to antibiotic therapy. The team’s findings are published this week in the Proceedings of the National Academy of Sciences (PNAS).
“We identified a new function important to antibiotic tolerance, which could be targeted to enhance the activity of our current antibiotics,” says lead study author Dr. Dao Nguyen, a scientist from the Translational Research in Respiratory Diseases Program at the RI-MUHC and an associate professor of Medicine at McGill University. “This is critical if we want to improve the efficacy of our antibiotics and prevent such treatments from failing.”
P. aeruginosa lung infection ,is the leading cause of death for thousands of people living with cystic fibrosis. This bacterium also causes many other serious infections in which in people with weakened defenses and immune system.
“P. aeruginosa causes lifelong lung infections in individuals with cystic fibrosis, and these infections cannot be cleared, even by cocktails of the most potent antibiotics available,” says Dr. Nguyen, who is also a respirologist at the McGill University Health Centre.
A “Nightmare bacteria” that grows slowly
P. aeruginosa has been listed among the “nightmare bacteria” by the Centers for Disease Control and Prevention (CDC) in the United States, with an estimated 51,000 healthcare-associated infections each year resulting in around 400 deaths. It is a common cause of healthcare-associated infections such as pneumonia, bloodstream or urinary tract infections, and surgical site infections
“Many bacteria, such as P. aeruginosa, when they grow slowly or do not grow at all, become tolerant to antibiotics,” explains Dr. Nguyen. “This is a crucial problem because many chronic infections are caused by bacteria that are slow growing or enter a dormant state when they reside in a living host, and this causes treatments to fail or infections to relapse in patients.”
A new enzyme target for antibiotics
In this newest research, Dr. Nguyen and her team have discovered that when P. aeruginosa is under stress or lacking nutrients, it uses a stress signaling system and defense enzyme (superoxide dismutase) to modify its cell membrane, making it less permeable to molecules and preventing antibiotics from penetrating the cell.
Researchers found that inhibition of the enzyme activity or the stress signaling system could render the pathogen more susceptible to antibiotics.
“Up until now antibiotic tolerance in slow growing bacteria was widely attributed to the fact that targets of antibiotics were not available or inactive in ‘dormant’ cells. With this research we have shown there is more to it than that” explains Dr. Nguyen. “We identified a new link between the stress defense enzyme, the regulation of membrane permeability and antibiotic tolerance.”
“In the long run, the discovery of this promising cellular target could expand the utility of our antibiotics and make new ones more effective,” she concludes.
Story Source:
Materials provided by McGill University Health Centre.
Journal Reference:
Dorival Martins, Geoffrey McKay, Gowthami Sampathkumar, Malika Khakimova, Ann M. English, Dao Nguyen. Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary-phase Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences, 2018; 201804525 DOI: 10.1073/pnas.1804525115
Cite This Page:
McGill University Health Centre. “New means to fight ‘un-killable’ bacteria in healthcare settings: Canadian scientists identify new cellular target to weaken P. aeruginosa — a severe threat to patients with cystic fibrosis.” ScienceDaily. ScienceDaily, 13 September 2018

Nurses File Lawsuit Against U-M Health System In Midst Of Strike Vote

Nurses at Michigan Medicine, the medical arm of the University of Michigan, have filed a federal lawsuit against the university, alleging it isn’t letting them wear pro-union buttons and T-shirts. The filing comes as the 5,700 union nurses are in the midst of voting on whether to authorize a strike as contract talks between the two sides have stalled.
“Our nurse bargaining team believes it is time to hold management accountable for bad faith bargaining, making changes to our working conditions without any negotiations and discriminating against RNs for exercising our right to free speech,” Megan Duncan, RN, a nurse at the University of Michigan Hospital, said in a news release.
The nurses also filed  four unfair labor practice charges with the Michigan Employment Relations Commission, alleging university officials are violating Michigan labor law, including failure to bargain in good faith; making changes in work shifts without notifying or negotiating with the union; refusing to bargain in good faith over terms and conditions of employment, and discriminating against union members who are engaged in legally protected speech in support of their right to collective bargaining.
“Time and again, university administrators have shown blatant disregard and disrespect for the rights of nurses,” John Karebian, executive director of the Michigan Nurses Association, said in a news release. “Anyone who thinks our members can be scared into silence doesn’t know much about nurses or the nursing profession.”
Not so, said Michigan Medicine spokeswoman Mary Masson.
“Michigan Medicine is confident all of its efforts in these negotiations have been consistent with the First Amendment and putting our patients first,” she said in a statement. “We will vigorously defend the university from this lawsuit that further hinders our ability to reach a contract agreement. We remain opposed to the union’s efforts to bring labor negotiations into patient care areas.
“We stand ready to continue contract talks.”
The two largest issues during the contract talks are wages and staffing ratios. On the latter, the union wants U-M to codify in writing the current staffing levels as the minimum levels not to be reduced, according to the unfair labor practice allegation filed by the union.
Nurses have been showing up to meetings of the U-M Board of Regents for the past several months to protest the direction of the talks. The nurses will vote until Sunday on whether to authorize a strike against the health system.
Masson said U-M has been fair in its offers.
“Michigan Medicine has offered the nurses a compensation package that includes competitive across-the-board increases of at least 3 percent and a competitive paid maternal/parental leave program that includes six weeks of paid leave for physiological recovery from birth of a child and six weeks of paid parental leave to employees after a birth, adoption or foster care and guardianship,” she said. “(The nurses union) cites safe staffing as one of its most important bargaining issues. In August, Michigan Medicine was ranked No. 5 in the nation by U.S. News & World Report. These honor roll rankings are achieved in part by our excellent nurse-to-patient ratios. Our ratios are in the top 2 percent of all hospitals in the country. We accomplished this without any contractual requirement to do so because excellent nurse staffing supports excellent patient outcomes. We remain committed to providing this level of staffing.
“If any of our nurses go out on strike, their absences may put patient safety at serious risk. Strikes are illegal for public employees in the state of Michigan. If an employee goes on strike, the employee is not paid for the time out on strike.”
David Jesse | Source: Detroit Free Press

Nursing And Midwifery Council Of Nigera Opens Portal For November Exams Registrations

RE: NOVEMBER 2018 PROFESSIONAL EXAMINATION FOR GENERAL AND POSTBASIC NURSES- OPENING OF THE EXAMINATION PORTAL
I am directed to inform you that the Council’s Examination portal is opened from Monday September 17th – Sunday September 30th, 2018 for all your eligible candidates for November 2018 Professional Examination for General and Post basic Nurses to complete the online application for the examination. Please note that there will be no extension after this date and all payment of the examination fee MUST be done within this same period.
I am further directed to inform you that all basic students with 2018 index number are not eligible for this examination but if you have such students, a written explanation has to be made to the Registrar stating why this is so and his approval must be gotten before your student will go online to apply for this examination otherwise, such exams applications will be rejected.
However on the payment process, the Examination fees of N38,500 for Basic Nursing programmes in Schools of Nursing/Department of Nursing and N41,250 for Post Basic Nursing programmes as applicable to your school is to be paid by each of your candidate to Nursing and Midwifery Council of Nigeria through remita platform in any of the commercial banks. The total sum for the school should be paid in bulk in the name of the school through remita. After successful online application and payment, a covering letter stating the names of the students who had applied for online Examination application with the original tellers of payment (remita payment slip) should be sent to the Registrar’s office in Abuja immediately after payment has been made.
For fresh candidates, the consultancy fees of N2,995 for Basic Nursing programmes in Schools/Department of Nursing and N3,187.50 for Post Basic Nursing programmes as applicable will appear on the portal and on the netpostpay slip. This should be paid individually to netpost pay through NIBBS e-bills payment platform in any commercial banks or acceptable payment channels such as debit card payment or internet banking payment platform.
Please note that amount that will appear as consultancy fees for resit candidates depends on the number of papers each resit candidate is resitting.
You are expected to pass this information to all your students and guide them properly to ensure that they initiate the right application on the portal. Your cooperation is essential to achieve this please.
Thank you for your usual support in promoting and maintaining excellence in Nursing Education and Practice.
Signed
Anslem-Nnadi Mercy (Mrs)
HOD Exams
For: Secretary-General/Registrar
Nursing and Midwifery Council Of Nigeria
Plot 713, Cadastral Zone, Behind Julius Berger Clinic
Life Camp, Gwarimpa
Abuja

Get Involved In NANNM Elections, Nursing Ambassadors Of Nigeria Calls Out To All Members

NANNM UNIT ELECTION
Sequel to the forthcoming unit election of NANNM nationwide, it has come to the notice of the Nursing Ambassadors of Nigeria that majority of the senior Nurses have started intimidating the 21st century Nurses with the aim of scaring them/us from contesting the key positions at their respective units (Unit Chairman & Secretary) that will grant us the eligibility of becoming automatic delegates at the next year State & National election of NANNM in order to effect the needed positive change of leadership of NANNM at both the State & National level.
On this note therefore, 
1) All the 21st century Nurses under the platform of Nursing Ambassadors of Nigeria are urged & advised to get involve in the forthcoming Unit election of NANNM at their respective units.
2) Ensure to get your NANNM membership card at the state NANNM headquarter, 10, calabar-Itu highway, Uyo with the sum of #1500
3) Endeavour to meet the NANNM constitutional requirements that gives you the eligibility to contest (be voted for) & to be a delegate (to vote) which are:
(a) NANNM membership card.
(b) Practicing License.
4) Resist any attempt by the Senior Nurses who posses evil ideology of scaring you out of the contest, & report same to any officials of the Nursing Ambassadors of Nigeria.
5) Be concerned & proactive at your respective unit about the issue of NANNM leadership & future of Nursing profession.
6) Know that without fixing the 21st century Nurses at the strategic position of leadership, our voice may not be heard & the positive change we are agitating for may not be realistic.
With:
One voice, One mind, One heart,
One vision, One dream,
Cooperation, we can do it.
Our campaign slogan: “ON THE WHEELS TO POSTERITY”
Let’s make Nursing great again.

Vaccine-derived polio: All you need to Know about vaccine-derived polio

Q: What is vaccine-derived polio?

A: Oral polio vaccine (OPV) contains an attenuated (weakened) vaccine-virus, activating an immune response in the body. When a child is immunized with OPV, the weakened vaccine-virus replicates in the intestine for a limited period, thereby developing immunity by building up antibodies. During this time, the vaccine-virus is also excreted. In areas of inadequate sanitation, this excreted vaccine-virus can spread in the immediate community (and this can offer protection to other children through ‘passive’ immunization), before eventually dying out.

On rare occasions, if a population is seriously under-immunized, an excreted vaccine-virus can continue to circulate for an extended period of time. The longer it is allowed to survive, the more genetic changes it undergoes. In very rare instances, the vaccine-virus can genetically change into a form that can paralyse – this is what is known as a circulating vaccine-derived poliovirus (cVDPV).

It takes a long time for a cVDPV to occur. Generally, the strain will have been allowed to circulate in an un- or under-immunized population for a period of at least 12 months. Circulating VDPVs occur when routine or supplementary immunization activities (SIAs) are poorly conducted and a population is left susceptible to poliovirus, whether from vaccine-derived or wild poliovirus. Hence, the problem is not with the vaccine itself, but low vaccination coverage. If a population is fully immunized, they will be protected against both vaccine-derived and wild polioviruses.

Since 2000, more than 10 billion doses of OPV have been administered to nearly 3 billion children worldwide. As a result, more than 13 million cases of polio have been prevented, and the disease has been reduced by more than 99%. During that time, 24 cVDPV outbreaks occurred in 21 countries, resulting in fewer than 760 VDPV cases.

Until 2015, over 90% of cVDPV cases were due to the type 2 component in OPV. With the transmission of wild poliovirus type 2 already successfully interrupted since 1999, in April 2016 a switch was implemented from trivalent OPV to bivalent OPV in routine immunization programmes. The removal of the type 2 component of OPV is associated with significant public health benefits, including a reduction of the risk of cases of cVDPV2.

The small risk of cVDPVs pales in significance to the tremendous public health benefits associated with OPV. Every year, hundreds of thousands of cases due to wild polio virus are prevented. Well over 10 million cases have been averted since large-scale administration of OPV began 20 years ago.

Circulating VDPVs in the past have been rapidly stopped with 2–3 rounds of high-quality immunization campaigns. The solution is the same for all polio outbreaks: immunize every child several times with the oral vaccine to stop polio transmission, regardless of the origin of the virus.

2018 polio outbreak in Papua New Guinea: advice for clinicians

In June 2018, the Government of Papua New Guinea notified the World Health Organization (WHO) of an outbreak of circulating vaccine-derived poliovirus.

The Government of Papua New Guinea is working with partners, including WHO and UNICEF, to take appropriate outbreak response measures including contact tracing, testing and vaccination.

Polio is very unlikely to spread in Australia because of high rates of vaccine coverage, good sanitation, and the quality and ability of the health system to respond to cases.

Recommendations for Vaccination

  • Australian residents planning to visit PNG for less than 4 weeks should be up to date with their polio vaccination. For adults, this is a 3 dose primary course, with a booster within the last 10 years. For children, a 3 dose primary course with a booster at 4 years old is currently recommended. These recommended vaccines may be given before arrival in PNG.
  • Australian residents travelling to PNG intending to stay for longer than 4 weeks should have a documented polio booster within 4 weeks to 12 months prior to the date of departure from PNG. The booster may be given before arrival in PNG, as long as it is given within 4 weeks to 12 months prior to leaving PNG.
  • Individuals who are already residing in PNG for 4 weeks or longer should have a documented polio booster within 4 weeks to 12 months prior to departure from PNG (refer to WHO’s International Travel and Health website). The booster may have been given before arrival in PNG, as long as it has been given within 4 weeks to 12 months prior to leaving PNG. Individuals leaving PNG in less than 4 weeks should still receive a polio booster as this will still have benefit.

Documentation

Consistent with WHO recommendations, polio-affected countries may require proof of vaccination when leaving the country.

Documentation should be provided on an International Certificate of Vaccination or Prophylaxis (“Yellow Book”). Copies of the International Certificate of Vaccination or Prophylaxis Booklets can be ordered from WHO Press or downloaded from the WHO website.

Polio vaccines

Polio vaccine boosters can be given as inactivated polio vaccine (IPV) either alone (IPOL) or as part of another vaccine, such as in combination with diphtheria, tetanus and pertussis (eg Boostrix IPV, Adacel Polio).

Polio vaccine boosters can also be given as oral polio vaccine (OPV). OPV is not available in Australia.

Further advice about polio vaccines can be found in the Australian Immunisation Handbook.

What Does it Mean to Be A Nurse?

BEING A NURSE MEANS…..

You will never be bored,
You will mostly be frustrated 🤔🤔🤔
You will be surrounded by challenges, so much to do and so little time
You will carry Immense responsibilities and very little authority,
You will step into people’s lives and make a difference, some will bless you some will curse you, You will see people at their worst and at their best You will never seize to be amazed at people’s capacity for Love, courage and endurance,
You will see life begin and end
You will experience resounding triumphs and devastating failures,
You will cry alot 😥😥
You will laugh alot.
You will know what it is to be human and to be humane.

Being a nurse is everything. You sacrifice alot that can only be appreciated by the almighty GOD himself, you are brave my Sisters so are you my brothers.

NDP 2019: 15,000 nurses, health professionals may lose jobs under 2019 budget -Drilon

Thousands of government nurses and other health personnel who are deployed in the country’s far-flung barangays from Batanes to Jolo stand to lose their jobs due to the Department of Budget and Management’s (DBM) move to cut the budget of the Department of Health (DoH), according to Senate Minority Leader Franklin M. Drilon.

“If we will just follow the proposed budget of the Department of Health, about 15,000 nurses and health professionals will lose their jobs,” Drilon said after grilling officials during the Senate hearing on the proposed P71 billion budget of the DoH.

“This is a vey serious concern. I have not seen in my 20 years in the Senate that a budget is slashed this much and the budget of the DoH at that,” Drilon said.

“This is injustice and I will not allow the budget to be passed unless this injustice is addressed,” Drilon added.

At the hearing, Drilon grilled a representative from the Department of Budget and Management for cutting the budget of the DoH by P36.2 billion from P107.3 billion in 2018 to P71 billion in 2019, particularly for health human resources deployment (HHRD) which was decreased from P9.59 billion in 2018 to P1.17 billion next year.

Dir. Jane Abella, a representative from DBM, argued that the budget was just transferred to Miscellaneous and Personnel Benefit Fund (MPBF) pending a review by the department and the Commission on Civil Service.

“Fifteen thousand nurses and health professionals will be on the streets while we are evaluating. Can you imagine the effect of this on our 15,000 workers and their performance? What kind of planning is this? Drilon asked.

Drilon said that it is not correct to transfer the funds of active government health personnel to MPBF, fearing it will not be released “without Malacanang’s clearance.”

Instead of reducing the number of health personnel, Drilon said that the DBM should regularize the 26,000 health workers, who are on job order status.

“You cannot have an ‘endo’ situation in the DoH, because the services will be affected. Let us regularize them so that we can provide stability to our health system,” Drilon said.

Drilon proposed that an errata be submitted by the DBM “in order to correct this injustice,” saying that it should not be the Senate scrambling to look for funds to restore the budget, which can be vetoed by the President.

Asked where to source the funds, Drilon said: “We have the budget. Even if we don’t have, reduce some other items in the budget in order to provide the budget for the DoH. Remove the fat in the budget in order to provide funds for the DoH.”

Drilon also questioned DBM’s move to reduce the DoH’s budget for health facilities enhancement program to P50 million in 2019 from the current level of P30.26 billion.

“This is something unusual that is why I am alarmed. This is something worrisome,” Drilon said.

The DBM representative pointed to DoH’s underutilization of the budget to justify the budget cuts.

To which Drilon replied: “So that is a punishment. The DoH should show to DBM that it can perform and if it doesn’t perform, we would just let the poor patients suffer?”

Drilon thus asked the DBM to submit an amendment to the budget to provide enough funds for the construction and maintenance of health facilities throughout the country. (via Senate website)

Vacancies for Foreign Nurses in Saudi Arabia 2018

Al HOKAIL MEDICAL GROUP – AL KHOBAR SAUDI ABIA

QUALIFICATION:
Female Registered Nurse
At least 2 year’s experience
With Saudi Lic.

SPECIAL AREA ASSIGN:
Derma
Hair Laser
Day Surgery
OR
IVF Reproduction
OB Gyne
Dental

FREE
Airline ticket
Medical Insurance
Transportation, Accommodation, Food

REQUIREMENT
PASSPORT,COE,PRC LICENSE

Send your cv now
sha@camox.com

Contact for more details-
09201548316-SMART
09661847228 –GLOBE

Beware of Illegal Recruiters!!

Vacancies for Female Caregivers in UAE 2018/2019

One of the Home care is hiring for 3 FEMALE CAREGIVERS available in UAE and can join IMMEDIATELY..

Position : Caregiver (Female)
Location : Al Ain
Experience: Patient Care for 2 years
Salary 3000 aed
Free Accommodation and Transportation

Interested candidates send cv to nicky@gulfhealthrecruit.com